Campion's high school curriculum is college preparatory in nature and content. Thus far, 100% of Campion high school graduates have gone on to study at 4-year colleges. Students follow a rigorous Classical core curriculum, which includes:

English: four years: American Literature, World Literature, English Literature, Modern Literature

Math: four years, from among Algebra, Algebra II, Geometry, Advanced Mathematics, Trigonometry, and Calculus AB

History: four year core: American History, Modern European History, World History, and United States Civics

Sciences: four years, including Biology, Chemistry, Physics, and Human Anatomy & Physiology

Theology & Philosophy: four years, including Logic, Intro to Philosophy, the Catechism of the Catholic Church, and Intro to Theology

Latin: four years, including Introductory Latin, Latin II, Latin Literature, Latin: Vergil; these courses prepare interested students to take the AP Latin Literature and AP Latin: Vergil exams in their Junior and Senior year.

Classical Civilization: four years, weekly afternoon seminar covering Greek, Roman, and the foundation of Christendom

Greek: four years of introductory and intermediate Greek, including Old and New Testament Greek

Speech & Drama: (one day per week, plus scheduled practices) fours years, including Public Speaking and performing plays such as Shakespeare's Twelfth Night (2008) and Oscar Wilde's The Importance of Being Ernest (2009).

Studio Art & Art History: four years, including Introduction to the Sacred Arts

Health & Physical Education: two years